Commentary - African Journal of Diabetes medicine (2023)

The interplay between cholesterol levels and diabetes risk
Department of Laboratory Science, Hormozgan University of Medical Science, Iran

*Corresponding Author:

Kelly Shan, Department of Laboratory Science, Hormozgan University of Medical Science, Iran, Email:

Received: 01-Aug-2023, Manuscript No. ajdm-23-115947 ; Editor assigned: 03-Aug-2023, Pre QC No. ajdm-23-115947(PQ); Reviewed: 17-Aug-2023, QC No. ajdm-23-115947 ; Revised: 22-Aug-2023, Manuscript No. ajdm-23-115947(R); Published: 29-Aug-2023, DOI: 10.54931/AJDM-31.4.7.


High cholesterol levels and diabetes are both significant health concerns worldwide, and they share some common risk factors. While one does not directly cause the other, there are several ways in which cholesterol levels and diabetes risk can be interconnected. Cholesterol is a fatty substance found in the blood that plays essential roles in various bodily functions. Two primary types of cholesterol exist: Low-density lipoprotein and high-density lipoprotein. High levels of LDL cholesterol, often referred to as “bad” cholesterol, can contribute to the development of atherosclerosis, a condition in which fatty deposits accumulate in the arteries, increasing the risk of cardiovascular diseases like heart attacks and strokes.

Diet and lifestyle choices significantly impact cholesterol levels. Consuming a diet high in saturated and trans fats, as well as excess calories, can lead to elevated LDL cholesterol levels. Obesity and physical inactivity are also associated with unfavorable lipid profiles. While high cholesterol itself does not directly cause diabetes, some of the same lifestyle factors that contribute to elevated cholesterol levels can also increase the risk of developing type 2 diabetes. Obesity is a well-established risk factor for both high cholesterol and type 2 diabetes. Excess body fat, especially around the abdomen, can lead to insulin resistance, a hallmark of type 2 diabetes. A diet high in saturated and trans fats not only raises LDL cholesterol levels but can also contribute to insulin resistance. Over time, this may increase the risk of developing type 2 diabetes. Chronic inflammation is linked to both high cholesterol and diabetes. Inflammation can impair insulin sensitivity and promote the development of atherosclerosis.

Family history can play a role in both conditions. People with a family history of high cholesterol or diabetes may be genetically predisposed to these conditions. Insulin resistance, a key factor in type 2 diabetes, can be exacerbated by high cholesterol levels, as the cholesterol buildup in arteries may impair blood flow and insulin delivery to tissues. While these connections between cholesterol levels and diabetes risk factors exist, it’s essential to emphasize that managing one’s cholesterol levels through lifestyle changes and, if necessary, medication, can significantly reduce the risk of cardiovascular diseases. Similarly, adopting a healthy lifestyle, including maintaining a balanced diet, engaging in regular physical activity, and maintaining a healthy weight, can help lower the risk of developing type 2 diabetes.

In conclusion, high cholesterol levels do not directly cause diabetes, but they share common risk factors and interrelated mechanisms. By addressing these risk factors through healthy lifestyle choices, individuals can reduce their risk of both high cholesterol and type 2 diabetes while promoting overall well-being. It’s crucial to consult with healthcare professionals for personalized guidance on managing these conditions and minimizing their associated risks. Individuals concerned about their cholesterol levels and diabetes risk should work closely with healthcare professionals to develop personalized strategies. These strategies may include regular screenings, dietary modifications, increased physical activity, and medication when necessary. By taking proactive steps to manage these risk factors, individuals can enhance their overall health and reduce the likelihood of experiencing complications related to high cholesterol and diabetes.



Conflict Of Interest

The author has nothing to disclose and also state no conflict of interest in the submission of this manuscript.

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