Atypical ketosis-prone diabetes
Author(s): Kiran Rathod

Atypical ketosis-prone diabetes is a form of diabetes seen in Africa, or in African migrants. It is characterised by an abrupt onset with hyperglycaemia or ketoacidosis (DKA), followed by periods of partial or complete remission. The causes of this syndrome, and whether it is a variant of type 1 (T1DM) or type 2 (T2DM) diabetes remain uncertain. This paper from Cameroon has investigated a group of classical T2DM patients (n = 124) with a group with ketosis-prone diabetes (n = 49). The latter group included 34 in the ketotic and 15 in the non-ketotic phase of disease. Investigations carried out included assessment of endogenous insulin secretion (C-peptide) and insulin resistance (HOMA). There were no significant differences between the type 1 and nonketotic phase atypical diabetic patients.


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